Antioxidant Activity and Immunomodulatory of Extracts From Roots of Actinidia kolomikta

Sun, Hongyi and Wang, Shaofei and Li, Shuhong and Yuan, Xi and Ma, Jian and Zhang, Zhenya (2013) Antioxidant Activity and Immunomodulatory of Extracts From Roots of Actinidia kolomikta. International Journal of Biology, 5 (3). pp. 1-12. ISSN 1916-9671

[thumbnail of 26791-89800-1-SM.pdf] Text
26791-89800-1-SM.pdf - Published Version

Download (314kB)

Abstract

Four extracts (AEA, AEB, AEC and AED), whose yields were 2.05%, 6.35%, 1.38% and 3.55%, respectively, were isolated and purified from the roots of Actinidia kolomikta in order to detect their antioxidant and immunomodulatory characteristics. In this study, AEC possessed the highest SOD-like activity (840.2 U/mg) and also showed stronger radical-scavenging activity (EC50, 152.2 ug/ml). In addition, for anti-proliferation, DLD-1 cells survival decreased to 30.8% at 50 ug/ml for 48 h by AEC. In this condition, the percentages of apoptosis cells were significantly increased from 0.85% to 17.30%. Moreover, AEB improved nitric oxide production and was shown to be more effective for immunomodulatory activity on macrophage survivals. The results indicate that all extracts from the roots of A. kolomikta exhibited strong antioxidant and immunomodulatory activities. These could provide a theoretical basis for A. kolomikta to be considered a nutritious functional material.

Item Type: Article
Subjects: Science Global Plos > Biological Science
Depositing User: Unnamed user with email support@science.globalplos.com
Date Deposited: 24 May 2023 07:45
Last Modified: 24 Jan 2024 04:21
URI: http://ebooks.manu2sent.com/id/eprint/939

Actions (login required)

View Item
View Item