Possibilities of Application of Transcatheter Treatment of Vascular Dementia with Binswanger’s Disease

INTRODUCTION: The research is dedicated to the main features of brain angioarchitectonics caused by the development of Binswanger’s disease (BD), as well as to the effectiveness of the method of transcatheter laser revascularization of cerebral vessels in the treatment of this disease.

MATERIALS: We examined 23 patients with BD whose age ranged from 58 to 81, mean age 78, including 15 (65.22%) men and 8 (34.78%) women. The examination included Clinical Dementia Rate (CDR), Mini-Mental State Examination (MMSE), Index Bartels (IB), laboratory examination, scintigraphy (SG), rheoencephalography (REG), Computed Tomography (CT), Magnetic Resonance Imaging (MRI) and cerebral multi-gated angiography (MUGA).

14 (60.87%) patients underwent transcatheter interventions - Test Group.

9 (39.13%) patients had conservative treatment - Control Group.

RESULTS: Test Group: favorable clinical result - 9 (64.29%) cases; adequate clinical result - 5 (35.71%) cases; comparatively adequate and comparatively positive clinical results were not attained in any case.

Control Group: favorable and adequate clinical results were not achieved in any case; comparatively adequate clinical result was gained in 7 (77.78%) cases; comparatively positive clinical result - in 2 (22.23%) cases.

CONCLUSIONS: The method of transcatheter laser revascularization of cerebral vessels furthers natural angiogenesis, induces collateral and capillary revascularization both in ischemic areas and in closely located tissues, thereby improving cerebral blood flow. At the same time, laser energy promotes the restoration of metabolic processes in neurons. It significantly distinguishes the proposed method from conservative treatment.