hiPSCs: Reprogramming towards cell-based therapies

Woolwine, Phillip E. (2013) hiPSCs: Reprogramming towards cell-based therapies. Open Journal of Regenerative Medicine, 02 (03). pp. 61-73. ISSN 2169-2513

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Abstract

Stem cell therapies show great potential for use in regenerative medicine, though advancements in safe stem cell technology need to be realized. Human induced pluripotent stem cells (hiPSCs) hold an advantage over other stem cell types for use in cell-based therapies due to their potential as an unlimited source of rejuvenated and immunocompatible SCs which do not elicit the ethical and moral debates associated with the destruction of human embryos. Towards realization of this potential this review focuses on the recent progress in DNA-and xeno-free reprogramming methods, particularly small molecule methods, as well as addresses some of the latest insights on donor cell gene expression, telomere dynamics, and epigenetic aberrations that are a potential barrier to successful widespread clinical applications.

Item Type: Article
Subjects: Science Global Plos > Biological Science
Depositing User: Unnamed user with email support@science.globalplos.com
Date Deposited: 15 Mar 2023 12:54
Last Modified: 03 Jan 2024 06:54
URI: http://ebooks.manu2sent.com/id/eprint/318

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