In vivo Molecular Functional Aging and Gradual Senescence with hTERT Gene as Antiaging Interventions in Danio rerio

Kalyanaraman, Ramanathan and Boominathan, Vasuki and Francis, Rahul and Parthasarathy, Sudharsan and Chandran, Janani and Tharumasivam, Siva Vijayakumar (2024) In vivo Molecular Functional Aging and Gradual Senescence with hTERT Gene as Antiaging Interventions in Danio rerio. UTTAR PRADESH JOURNAL OF ZOOLOGY, 45 (18). pp. 371-389. ISSN 0256-971X

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Abstract

The study investigates the impact of resveratrol on zebrafish, a model organism, to understand the enzymatic responses and gene expression changes associated with aging. Zebrafish are significant in understanding human diseases and comparing them with zebrafish. The study reveals significant variations in muscle catalase, muscle super peroxide, and muscle dismutase, with a focus on the hTERT gene. The study also reveals senescence-associated activity in muscle and abundant telomerase activity during aging. The study suggests that telomerase activity is strongly correlated with telomere shortening and replicative senescence. The study also compares resveratrol-treated zebrafish to the control group, revealing that intermediate concentrations of resveratrol show variations at the muscle level and prevent muscle damage. The results suggest that resveratrol treatment in zebrafish retains dye and has a positive effect on muscular tissue. These findings provide comprehensive knowledge in antiaging research and could potentially aid future research.

Item Type: Article
Subjects: Science Global Plos > Biological Science
Depositing User: Unnamed user with email support@science.globalplos.com
Date Deposited: 18 Sep 2024 07:02
Last Modified: 27 Sep 2024 08:20
URI: http://ebooks.manu2sent.com/id/eprint/2765

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