Importance of Zebrafish as a Non-Mammalian Vertebrate Model for Studying Neurodegenerative Disorders Using Ayurvedic Medicinal Plants: A Review

Pal, Subharthi and Mitra, Anisa and Ghosh, Rajarshi (2024) Importance of Zebrafish as a Non-Mammalian Vertebrate Model for Studying Neurodegenerative Disorders Using Ayurvedic Medicinal Plants: A Review. UTTAR PRADESH JOURNAL OF ZOOLOGY, 45 (1). pp. 56-70. ISSN 0256-971X

Full text not available from this repository.

Abstract

Alzheimer's disease and Parkinson's disease are debilitating neurodegenerative disorders that impose a significant burden on the affected individuals and the society as a whole. Despite extensive research efforts, effective treatments for these diseases remain elusive till date. Ayurveda, a traditional system of medicinal practice which originated in ancient India, has long touted the potential of various plants possessing neuroprotective properties. The effects of a few relevant Ayurvedic plants viz. Guduchi, Kapikachhu, Shankhapushpi, Turmeric, Mandukparni, Ashwagadha, Brahmi, Jatamansi etc. on several non-human primates and rodents have been reported. The therapeutic potential of those plants to mitigate the pathological hallmarks associated with Alzheimer's disease and Parkinson's disease was assessed. We have outlined the most recent research on Ayurveda's effects on neurodegenerative brain illnesses in this review article, with an emphasis on Alzheimer's disease and Parkinson's disease. As the zebrafish (Danio rerio Hamilton) has emerged as a useful, non-mammalian vertebrate model organism for studying a wide range of diseases, the effect of few other medicinal plants on zebrafish was also mentioned. Powerful live imaging and genetic tools which is currently available for zebrafish has transformed this fish to a top model in biomedical research and toxicity testing. However, further research is needed to elucidate the precise mechanisms of action and to translate these promising results into clinical applications. The exploration of traditional medicinal systems, in conjunction with modern scientific methodologies using novel model organisms, such as zebrafish offers a valuable avenue for the development of innovative treatments for neurodegenerative disorders.

Item Type: Article
Subjects: Science Global Plos > Biological Science
Depositing User: Unnamed user with email support@science.globalplos.com
Date Deposited: 17 Jan 2024 13:01
Last Modified: 17 Jan 2024 13:01
URI: http://ebooks.manu2sent.com/id/eprint/2439

Actions (login required)

View Item
View Item