Influence of Urethane on Rheological Properties of the Erythrocytes in Rats: Recent Advancement

Therapeutic strategies using various preparations and their combinations with different mechanisms
of action are gaining increasing attention. But the experiments are carried out in accordance with the
work ethic on animals using anesthetics, which change the internal environment. We examined effect
of urethane on rheological properties of erythrocytes in rats. Our results demonstrated negative effect
resulting in worsens deformability and aggregability of the erythrocytes. Therefore studies on the
effect of drugs to hematological parameters and blood rheology which were performed on urethane
anesthetized animals, should be considered invalid and incorrect.