AMELIORATIVE POTENTIAL OF PLANTS AND BIOACTIVE COMPONENTS IN FLUORIDE-INDUCED TOXICITY: A MINI-REVIEW

Fluoride toxicity is declared one of the severe threats by many countries globally. Fluoride pollution has received much attention in recent decades due to its toxicity-related disorders in humans and animals. It is responsible for the majority of groundwater-related diseases that enter water sources via natural and anthropogenic pathways. Fluoride accumulates in the body, causing disruption of cellular respiration, oxidative damage, and changes to the antioxidant enzyme system. As a result, the apoptotic machinery is also triggered. Several physical methods are available for the defluoridation of water, but these techniques are still inaccessible in many backward areas. Hence, remedial approaches such as plant extracts and bioactive components with antioxidant qualities that protect cells from fluoride-induced oxidative stress are urgently needed. This review aims to explore the available therapy options for fluoride-induced oxidative stress using plant extracts and bioactive components.