Deactivation DNA Polymerase and Hexokinase Enzymes by Radioisotope 28Mg in Cancer Treatment Research: An Advance Study

Cancer cells are distinct from healthy cells in that they grow rapidly, uncontrollably, and rarely die. They need more enzymes in terms of quantity than healthy cells for their metabolic processes, with two enzymes in particular: hexokinase and DNA polymerase. Enzymes are fascinating because they catalyze energy metabolism and DNA replication. They both have the magnesium metal ion as a cofactor. The use of beta-decay radioisotopes to deactivate cofactor enzymes by replacing stable metals with beta-decay radioisotopes is a recent development in cancer treatment research. 28Mg is used to substitute a stable Mg in the enzymes in this study. Hexokinase that has been deactivated has the potential to disrupt or stop the supply of energy to tumor cells.DNA replication can be slowed or disrupted if DNA polymerase is inactive. Tumors may be stopped in their tracks and even killed if these two vital mechanisms are disrupted. Besides, deactivating radioactive isotopes will bombard tumor cells on the spot with a nearly 100% chance of hitting.