Determination of Non-Pituitary down Regulation Protocol for Ovulation Induction in ART (IVF & ICSI)

This study should prove that consumption of gonadotropins is less and the time of ovulation induction is less so less cost effect benefit. ART (IVF/ ICSI) is a multistep process involving ovarian stimulation, ovulation induction, collection of oocytes, fertilization with sperm, and transfer of the fertilized oocytes to the uterus for implantation and maturation.

With the advent of numerous ovarian stimulation protocols, the pregnancy outcome has significantly improved. Pituitary downregulation gives better results in terms of oocyte quantity and quality, which results in more embryos and more embryos being frozen for later transfer to the patient's uterus.

From literature we found that pregnancy outcome in minimal stimulation protocol gives almost the same result, especially in advanced patients age with less side effect. In our study on 1652 patients who admitted for ICSI and started their ovarian stimulation by HMG or FSH without pituitary down regulation protocol. This protocol gives the pregnancy outcome same as in the other protocols with less side effects and low coast. The recent development of GnRH antagonists has offered an alternative approach in IVF treatment with no significant difference in pregnancy outcome. The use of antagonist protocol to be safer in PCO patients.