Ai, Hong-Wei and Kang, Yue-Xin and Cao, Yang and Zheng, Cheng-Jian (2014) Antifungal Properties and Chemical Analysis of Essential Oil from Vitex negundo Seeds. British Journal of Pharmaceutical Research, 4 (5). pp. 541-548. ISSN 22312919
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Abstract
Aims: To investigate the constituents and antimicrobial activity of essential oil from Vitex negundo seeds.
Study Design: The essential oil of Vitex negundo seeds was prepared by hydrodistillation. GC/MS technique was used to determine the volatile constituents in the oil. A total of 13 isolates of bacteria and fungi were employed to evaluate the antimicrobial activity of the oil.
Place and Duration of Study: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, between April 2010 and September 2010.
Methodology: Essential oil from Vitex negundo seeds were obtained by hydrodistillation, with constituents analyzed by GC-MS. Antimicrobial activity of the oil was evaluated against both Gram-positive and Gram-negative bacteria and fungi.
Results: A total of forty-two components, representing 91.36% of the oil, were identified. n-Hexadecanoic acid (17.68%), eudesm-4(14)-en-11-ol (12.39%) and caryophyllene oxide (10.79%) were found to be the major constituents. The essential oil exhibited significant antifungal activity against Candida albicans at MIC 4.0 μg/ml.
Conclusion: The essential oil of Vitex negundo seeds showed potential antifungal activity and can be of potential use in pharmaceutical fields.
Item Type: | Article |
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Subjects: | Science Global Plos > Medical Science |
Depositing User: | Unnamed user with email support@science.globalplos.com |
Date Deposited: | 17 Jul 2023 06:15 |
Last Modified: | 27 Nov 2023 04:34 |
URI: | http://ebooks.manu2sent.com/id/eprint/1180 |