The Prophylactic Effect of some herbs extract on Gentamicin Induced Nephrotoxicity in Albino Rats

Nephropathies and particularlynephrotoxicity have been recognized as powerful reasonsof life-threatening illnesses due to frequent exposure to xenobiotic whether by environmental contaminationor by drugs misuse. This study aimed to investigatethe protectingimpacts of alcoholic extract of Cinnamomum zeylanicum and Zingiber officinale on gentamicin induced nephrotoxicity. Thirty six healthy adult albino male rats weighing (170±10 g), were bought for the study. They were grouped into 6 equal groups; group (G-) was kept as a negative control, group (G+) was fed on basal diet and treated with gentamicin as a positive control group. Group 1 and group 2 were also fed on basal diet + oral doses of herbal extract of Cinnamomum zeylanicum (100 and 200 mg kg-1b.w. respectively), while group 3 and 4 were fed with Zingiber officinale extracts (100 and 200 mg kg-1b.w respectively) once a day, for a period of 28 day. On the 22nd day of the administration, all groups except (G-)group (normal rats) were injected with gentamicin (80 mg kg-1. b.wt. i.p.) dailyfor 8 consecutive days. Assessment of hemogram, some serum biochemical parameters, and histopathology of kidneys were assessed. Chemical composition of Cinnamon and Ginger were analysed by High Performance Liquid Chromatography (HPLC). The results revealed that cinnamon and ginger alcoholic extracts improved the biological evaluation, kidney functions, and antioxidant enzyme activity compared to control+ group. The study showed that feeding rats with cinnamon and ginger have markedly protected them against the harmful impacts of gentamicin on kidney.