Preparation of chitosan/gelatin nanofibers containing triamcinolone by electrospinning and investigation of drug release

Behbood, Leila and Moradipour, Pouran and Arkan, Elham (2020) Preparation of chitosan/gelatin nanofibers containing triamcinolone by electrospinning and investigation of drug release. Medical Journal of Tabriz University of Medical Sciences and Health Services, 42 (2). pp. 135-142. ISSN 1608-5671

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Abstract

Background: In the present study, a biocompatible drug delivery system was prepared by using chitosan-gelatin nanofibers based on electrospinning method.

Methods: The nanofibers were prepared by electrospinning and cross-linked by glutaraldehyde to stabilize in aqueous medium. The surface morphology and approximate size of nanofibers were investigated by the scanning electron microscopy and optical microscope.

Results: The nanofibers were characterized and the interaction types of drug-nanofiber matrix were evaluated by using FT-IR spectrum. The swelling of nanofibers was about 3.88% and the stability of nanofibers about 3 days was estimated.

Conclusion: The drug release experiment in phosphate buffer (PBS pH=7.4) showed that quick release occurred in early hours and then release rate was decrease and controlled release was continued for three more days. The results showed that the triamcinolone drug delivery system was well implemented and could be used as a functional patch in the future. Keyword: Nanofibers, Drug Delivery System, Swelling, Drug Release, Controlled Release

Item Type: Article
Subjects: Science Global Plos > Medical Science
Depositing User: Unnamed user with email support@science.globalplos.com
Date Deposited: 10 Jun 2023 06:14
Last Modified: 08 Jan 2024 13:19
URI: http://ebooks.manu2sent.com/id/eprint/1090

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