A Review of Potential Metal Toxicity and Mineral Deficiency in Autism

Sikarwar, Archana and Balakrishnan, Hema and Tong, Shiow and Vien, Koh and Yoong, Jason and Hao, Koo and Chin, Nang and Xuan, Kho and Jiayi, Lim and Yee, Tye (2015) A Review of Potential Metal Toxicity and Mineral Deficiency in Autism. International Journal of Biochemistry Research & Review, 7 (1). pp. 1-12. ISSN 2231086X

[thumbnail of Sikarwar712014IJBcRR13913.pdf] Text
Sikarwar712014IJBcRR13913.pdf - Published Version

Download (426kB)

Abstract

Autism is a neurodevelopmental disorder that predominantly affects the younger generation. The etiology which contributes to the occurrence of autism is not well defined. However, apart from genetic factors, environmental factors such as metal exposure have been controversial from the last decade. Contamination of several metals was proposed to be responsible for oxidative stress production, mitochondria dysfunction and immune abnormalities which lead to characteristics of autism in children. Objective of review is to analyze the relationship between the most studied toxic metals namely mercury, lead, cadmium and arsenic. Based on the findings, metal toxicity due to lead, mercury and aluminum are clearly exhibited meanwhile insufficient data were available on arsenic and cadmium. In addition, lack of essential minerals in autistic children who were exposed to heavy metals has also precipitated the autistic disorder. However, high quality epidemiological studies with minimal biasness should be conducted to support the correlation of heavy metal with autism.

Item Type: Article
Subjects: Science Global Plos > Biological Science
Depositing User: Unnamed user with email support@science.globalplos.com
Date Deposited: 10 Jun 2023 06:15
Last Modified: 09 Jan 2024 05:12
URI: http://ebooks.manu2sent.com/id/eprint/1004

Actions (login required)

View Item
View Item