Zbili, Mickael and Debanne, Dominique (2019) Past and Future of Analog-Digital Modulation of Synaptic Transmission. Frontiers in Cellular Neuroscience, 13. ISSN 1662-5102
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Abstract
Action potentials (APs) are generally produced in response to complex summation of excitatory and inhibitory synaptic inputs. While it is usually considered as a digital event, both the amplitude and width of the AP are significantly impacted by the context of its emission. In particular, the analog variations in subthreshold membrane potential determine the spike waveform and subsequently affect synaptic strength, leading to the so-called analog-digital modulation of synaptic transmission. We review here the numerous evidence suggesting context-dependent modulation of spike waveform, the discovery analog-digital modulation of synaptic transmission in invertebrates and its recent validation in mammals. We discuss the potential roles of analog-digital transmission in the physiology of neural networks.
Item Type: | Article |
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Subjects: | Science Global Plos > Medical Science |
Depositing User: | Unnamed user with email support@science.globalplos.com |
Date Deposited: | 27 May 2023 06:55 |
Last Modified: | 12 Jan 2024 07:15 |
URI: | http://ebooks.manu2sent.com/id/eprint/972 |