Biophysical parameters control signal transfer in spiking network

Garnier Artiñano, Tomás and Andalibi, Vafa and Atula, Iiris and Maestri, Matteo and Vanni, Simo (2023) Biophysical parameters control signal transfer in spiking network. Frontiers in Computational Neuroscience, 17. ISSN 1662-5188

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Abstract

Introduction: Information transmission and representation in both natural and artificial networks is dependent on connectivity between units. Biological neurons, in addition, modulate synaptic dynamics and post-synaptic membrane properties, but how these relate to information transmission in a population of neurons is still poorly understood. A recent study investigated local learning rules and showed how a spiking neural network can learn to represent continuous signals. Our study builds on their model to explore how basic membrane properties and synaptic delays affect information transfer.

Methods: The system consisted of three input and output units and a hidden layer of 300 excitatory and 75 inhibitory leaky integrate-and-fire (LIF) or adaptive integrate-and-fire (AdEx) units. After optimizing the connectivity to accurately replicate the input patterns in the output units, we transformed the model to more biologically accurate units and included synaptic delay and concurrent action potential generation in distinct neurons. We examined three different parameter regimes which comprised either identical physiological values for both excitatory and inhibitory units (Comrade), more biologically accurate values (Bacon), or the Comrade regime whose output units were optimized for low reconstruction error (HiFi). We evaluated information transmission and classification accuracy of the network with four distinct metrics: coherence, Granger causality, transfer entropy, and reconstruction error.

Results: Biophysical parameters showed a major impact on information transfer metrics. The classification was surprisingly robust, surviving very low firing and information rates, whereas information transmission overall and particularly low reconstruction error were more dependent on higher firing rates in LIF units. In AdEx units, the firing rates were lower and less information was transferred, but interestingly the highest information transmission rates were no longer overlapping with the highest firing rates.

Item Type: Article
Subjects: Science Global Plos > Medical Science
Depositing User: Unnamed user with email support@science.globalplos.com
Date Deposited: 27 Mar 2023 09:08
Last Modified: 07 Mar 2024 08:07
URI: http://ebooks.manu2sent.com/id/eprint/391

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