Endoscopically Assisted Repair of Nasal Septal Perforation Using Platelet Rich Plasma

Background: Nasal septal perforations (NSPs) are nasal septum defects as a result of necrosis to the cartilage or bony tissues in addition to their mucous membrane on both surfaces. the current work aimed to estimate endoscopically assisted repair of medium-sized nasal septal perforation using inferiorly based rotational flap together with Platelet rich plasma (PRP).

Methods: It was a randomized controlled double-blind study recruited on 40 cases with anterior septal perforation for endoscopic repair. Patients randomly were allocated into two equal groups: group A were cases with anterior septal perforation for endoscopic repair using inferior based mucosal rotational and septal flaps only and group B were patients subjected to inferior based mucosal rotational and septal flaps together with PRP. All participants were exposed to thorough history taking, laboratory, clinical examination, and radiological investigation.

Results: Number of patients who had complete or partial closure of septal perforation, was insignificantly different between both groups. Number of patients who had decrease in size of perforation, same size perforation, residual symptoms, and who were asymptomatic was insignificant difference between both groups. Times to disappearance of residual epistaxis and residual crustation were significantly earlier in group B in comparison with group A (P = 0.001 and 0.011 respectively).

Conclusions: Overall, PRP is a promising material for nasal septal perforation. Times to disappearance of residual epistaxis and residual crustation were remarkably earlier in group B in comparison with group A.