Studies on Increased Prevalence of Hernia, Uterine Descent, Fibrous Adhesions, Retroperitoneal Fibrosis and Germ Cells with Endogenous Estrogen

Background: Era of contraception, abortions, [20th, 21st centuries] implemented as family welfare schemes witnessed, increased prevalence of hernias, uterine descent, fibrous adhesions presenting as colic abdominal pain, retroperitoneal fibrosis, intestinal obstruction and volvulus.

Objectives: Altruistic association of contraception [if any], with increasing hernias, uterine descent, fibrous adhesions progressing to retroperitoneal fibrosis, volvulus, intestinal obstructions were sought after.

Methods: In 2012, retrospective analysis of, prevalence of hernia, uterine descent, in 350 patients of 20-35 years, 35-50 years, >50 years age groups, from data collected by convenient, stratified random sampling, from different geographical locations, between 2003-2012 and its association with presence, absence of contraception, abortion was undertaken; simultaneously, serum estrogen levels obtained from 105 patients, was also analyzed.

In ~2000-2012 clinical practice 25 patients were detected to have fibrous adhesions, related intestinal obstruction, volvulus and retroperitoneal fibrosis; they were analyzed for the correlation with status of contraception, hysterectomy and cholesterol deprived diet.

Results: 3-6 fold increase in hernia was seen in contraceptive users of >20years to >50 years with a p value of <0.0025 in 20-35 years, p value of <0.0005 in 35-50 years and the p value of <0.02 in >50 years: Fig. 2.

8- 9 fold increase in prevalence of fibrous adhesions in contraception users of >20 years to 50 years was seen with a p value of <0.0005 and 2 fold increase in retroperitoneal fibrosis and volvulus was seen in people using contraception and after hysterectomy with a p value of <0.025: Fig. 1.

Endogenous estrogen was reduced below normal in 61% of contraceptive users, 25% of contraceptive users had low normal serum estrogen with a p value of <0.0005: Fig. 3.

Cholesterol deprived diet; due to decreased synthesis of endogenous estrogen androgen also was associated with 50% increase in degenerative diseases including volvulus with fibrous adhesions.

Conclusion: Concept is acquired contraception, abortion status, with smashed fragmentation of germ cells, reduced endogenous estrogen: androgen, results in defaulted genomic repertoire, deranged cell cycle, cell metabolism, with increased degenerative pathologies including hernia, uterine descent and fibrous adhesions progressing to volvulus, retroperitoneal fibrosis, intestinal obstruction and metabolic syndrome.

Contraception reversal declined the diseases as a cause and effect phenomenon; corrective surgeries coupled with tubal recanalisation: contraception reversal was effective without recurrence and complications by restoration of genomic repertoire-figure supplementary file