Miller, Dannah R. and Ingersoll, Matthew A. and Chou, Yu-wei and Lin, Ming-Fong (2022) Statins Enhances Anti-Androgen Abiraterone Acetate Therapeutic Efficacy on Castration-Resistant Prostate Cancer Cells. In: New Horizons in Medicine and Medical Research Vol. 2. B P International, pp. 108-126. ISBN 978-93-5547-344-8
Full text not available from this repository.Abstract
Castration-resistant (CR) prostate cancer (PCa) treatment options are limited. A substantial sub-population of CR PCa tumors can synthesize androgens for intracrine androgen receptor (AR) activation, inhibiting androgen biosynthesis could be an effective treatment option for these patients.
Study Objective: The androgen biosynthesis inhibitors simvastatin, atorvastatin, and ketoconazole were found to directly inhibit growth, migration, and colony formation of androgen-independent LNCaP C-81 cells that exhibit de novo androgen biosynthesis, with simvastatin being the most effective. Importantly, statins specifically enhanced growth suppression in combination with anti-androgen abiraterone acetate effects on CR PCa cells.
Conclusion: Statins can be combined with abiraterone acetate to improve anti-androgen therapy for CR PCa.
| Item Type: | Book Section |
|---|---|
| Subjects: | Science Global Plos > Medical Science |
| Depositing User: | Unnamed user with email support@science.globalplos.com |
| Date Deposited: | 17 Oct 2023 05:43 |
| Last Modified: | 17 Oct 2023 05:43 |
| URI: | http://ebooks.manu2sent.com/id/eprint/1719 |
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