Ameliorative Effect of Aqueous Crude Extract of the Aerial Parts of Leonurus Cardiaca on Doxorubicin-Induced Cardiovascular Damage in Wistar Rats

Wellington, E. O. and Otobo, M. B. and Ogbomade, S. J. (2023) Ameliorative Effect of Aqueous Crude Extract of the Aerial Parts of Leonurus Cardiaca on Doxorubicin-Induced Cardiovascular Damage in Wistar Rats. International Journal of Biochemistry Research & Review, 32 (6). pp. 22-36. ISSN 2231-086X

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Abstract

This study investigated the ameliorative effect of aqueous crude extract of the aerial parts of Leonurus cardiaca on doxorubicin-induced cardiovascular damage in Wistar rats. Aqueous crude extract of Leonurus cardiaca was prepared based on standard Laboratory condition. A total of 55 male and female rats weighing between 170 ± 15 and 180±15g were used for this study. The rats were grouped into 11 groups of five rats per group. Group 1 and 2 served as normal and negative control rats respectively. Rats in group 3-11 were intraperitoneally administered 18mg/kg of doxorubicin once and were treated with the crude extract at 166, 250, and 500mg/kg for 7, 14, and 21 days. All biochemical, hematological, and histological analyses were carried out based on standard methods. The mean plasma troponin T and I, IL-6 and C-reactive protein concentrations of the negative control were 357.93±0.01 pg/mL, 241.51±0.00 pg/mL, 63.94±0.01 pg/dl, and 41.03±0.01 mg/ml respectively. The plasma troponin T and I, IL-6 and C-reactive protein concentrations treated for 21 days were 270.32±0.01 pg/mL, 217.84±0.01 pg/mL, 42.75±0.01 pg/dl, and 18.03±0.01 mg/ml respectively. The mean MDA, GSH concentrations, GPx, CAT and SOD activities in doxorubicin-induced cardiovascular damage rats, treated with the extract at 500mg/kg were 5.01±0.01mmol/l, 68.46±0.02µg/mg.protein, 70.21±0.01mg/pro.min, 141.62±1.80IU/g, and 19.05±0.02mg/g respectively and were significantly different from those of group 2. Aqueous crude extract of Leonurus cardiaca at 500mg/kg ameliorated the damage induced by doxorubicin on the heart tissues, hence could serve as a novel herbal agent for the treatment of cardiovascular damage.

Item Type: Article
Subjects: Science Global Plos > Biological Science
Depositing User: Unnamed user with email support@science.globalplos.com
Date Deposited: 09 Oct 2023 07:36
Last Modified: 09 Oct 2023 07:36
URI: http://ebooks.manu2sent.com/id/eprint/1687

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