Assessment of Microbial Etiology of Febrile Neutropenia

Mudshingkar, Swati and Natraj, Gita and Baveja, Sujata and Mehta, Preeti and Jijina, Farah (2023) Assessment of Microbial Etiology of Febrile Neutropenia. In: Research Developments in Medicine and Medical Science Vol. 7. B P International, pp. 182-195. ISBN 978-81-19102-79-2

Full text not available from this repository.

Abstract

Bacterial and fungal infections are a leading cause of morbidity and mortality in neutropenic patients. The empiric antimicrobial regimen is chosen based on the susceptibility pattern of locally prevalent pathogens. Blood and other clinical specimens from 64 febrile neutropenic patients with clinical sepsis have been processed to ascertain the bacterial and fungal spectrum and antimicrobial susceptibility pattern. A case-control study was used to identify risk factors for developing sepsis.

A total of 68 organisms were recovered. Fifteen (22.05%) were Gram-positive cocci with predominance of methicillin Sensitive S. aureus (10.29%), 47 (69.11%) were Gramnegative rods with predominance of Klebsiella pneumoniae (30.88%) and four were Non albicans Candida. 81% and 60% of Klebsiella and E. coli were ESBL producers. All species of Candida were sensitive to amphoterecin B and voriconazole. The duration and severity of neutropenia, chemotherapy, immunosuppressive therapy, altered mucosal barriers, and the existence of central venous lines were all statistically significant risk factors for developing sepsis. Gram-negative bacteria were the most prevalent isolates. Amongst the fungal isolates, non-albicans candida spp. were predominant. The selection of therapy for neutropenic patients should be based on the local spectrum of microbes as well as local and regional resistance patterns.

Item Type: Book Section
Subjects: Science Global Plos > Medical Science
Depositing User: Unnamed user with email support@science.globalplos.com
Date Deposited: 04 Oct 2023 05:24
Last Modified: 04 Oct 2023 05:24
URI: http://ebooks.manu2sent.com/id/eprint/1589

Actions (login required)

View Item
View Item